2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Panitumumab (anti-EGFR)

Panitumumab (anti-EGFR)  (Synonyms: 帕尼单抗 (anti-EGFR))

目录号: HY-P99041A 纯度: 98.00%
COA

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Panitumumab (anti-EGFR) 是一种全人源 IgG2 抗 EGFR 单克隆抗体，具有抗肿瘤活性。Panitumumab (anti-EGFR) 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab (anti-EGFR) 可用于癌症研究，例如结肠癌。

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Panitumumab (anti-EGFR) Chemical Structure

Panitumumab (anti-EGFR) Chemical Structure

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1 mg ￥1850
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5 mg ￥5600
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10 mg ￥8680
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Panitumumab (anti-EGFR) 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer[1][2][4].

同型

Human IgG2 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

Panitumumab (2 nM-2 μM，3 小时) (抗 EGFR) 抑制表达 EGFR 的 NCI-H1975 细胞、NCI-H1650 细胞和 CHO 细胞中的配体依赖性自磷酸化[3]。
Panitumumab (0 -200 μg/mL，48 h) (anti-EGFR) 抑制 DLD-1细胞的增殖[4]。
Panitumumab (80 μg/mL，24 h) (抗 EGFR) 增加 Caco-2 细胞和 DLD-1 细胞中的 beclin-1 (自噬标志物) 水平[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Panitumumab (anti-EGFR) 相关抗体:

Western Blot Analysis[3]

Cell Line: EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells
Concentration: 2, 20, 200, 2000 nM
Incubation Time: 3 h
Result: Inhibited ligand-induced autophosphorylation of EGFR.
体内研究
(In Vivo)

Panitumumab (2 nM-2 μM，3 小时) (抗 EGFR) 抑制表达 EGFR 的 NCI-H1975 细胞、NCI-H1650 细胞和 CHO 细胞中的配体依赖性自磷酸化[3]。
Panitumumab (0 -200 μg/mL，48 h) (anti-EGFR) 抑制 DLD-1细胞的增殖[4]。
Panitumumab (80 μg/mL，24 h) (抗 EGFR) 增加 Caco-2 细胞和 DLD-1 细胞中的 beclin-1 (自噬标志物) 水平[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H1975 and NCI-H1650 xenografts[3]
Dosage: 25, 100, or 500 μg/mouse
Administration: Intraperitoneal injection (i.p.), twice a week
Result: Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.
Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.
Clinical Trial
性状

液体

颜色

Colorless to light yellow

中文名称

帕尼单抗 (anti-EGFR)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.00%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Panitumumab (anti-EGFR) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Panitumumab (anti-EGFR)帕尼单抗 (anti-EGFR)EGFREpidermal growth factor receptorErbB-1HER1human IgG2anti-EGFRmonoclonal antibodyanti-tumorNCI-H1975NCI-H1650CHODLD-1Caco-2Inhibitorinhibitorinhibit

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